A deeper look at disease

Issue 16_Disc_A deeper look

Micro-optical coherence tomography enables studying the network of collagen fibres around the hole where the optic nerve exits the eye. Credit: Liu Linbo.

Techniques such as deep-tissue imaging can help in disease diagnosis as well as in understanding pathological processes and treatment outcomes.

Assoc Prof Liu Linbo, Dr Ge Xin and Dr Liu Xinyu of NTU’s School of Electrical and Electronic Engineering developed a fibre optic-based imaging technology that can be used in the diagnosis of medical conditions such as coronary artery disease, eye and skin disease, and gastrointestinal cancer.

Called micro-optical coherence tomography, it can be used to monitor processes such as inflammatory reactions to diseases and treatments in deep layers of tissue in real time.

The method can also capture the structured colours of deep tissue through an opaque medium, which means that it can probe nanoscale features invisible to existing microscopic technologies, thus adding nanoscopic information to the ultrahigh-resolution images obtained.

The researchers have filed for a patent on the technology and are trialling a prototype in clinical settings.

More details on the technology can be found in “Geometry-dependent spectroscopic contrast in deep tissues”, iScience (2019), DOI: 10.1016/j. isci.2019.08.046.
The article appeared first in NTU’s research & innovation magazine Pushing Frontiers (issue #16, February 2020). 

You may also like...